Pipeline > MCP-1
The MCP-1 program consists of glycan-binding decoy proteins based on the human protein monocyte chemotactic protein 1 (MCP-1). MCP-1 is a glycan-binding CC-chemokine which binds to the GPCR receptor CCR2, expressed on monocytes and macrophages.
Our glycan-binding MCP-1 decoy proteins have potent anti-inflammatory activity in a number of monocyte/macrophage-driven disease models in vivo, such as multiple sclerosis (EAE), myocardial infarction, restenosis and autoimmune uveitis. Given the broad involvement of macrophages and monocytes in many inflammatory agents, the MCP-1 program has very broad potential. More information on ProtAffin’s MCP-1 Program is available under CDA.